中药活性成分调控氧化应激水平对绝经后骨质疏松影响的研究进展

Study progress on the influence of active ingredient of traditional Chinese medicine mediate oxidative stress on Postmenopausal osteoporosis

绝经后骨质疏松主要是由于雌激素减少介导的骨代谢失衡,现有研究显示氧化应激是此病的重要发病机制。氧化应激和雌激素缺乏对成骨细胞和破骨细胞的影响,导致骨重塑失衡。近年来,中药活性成分防治绝经后骨质疏松的研究日益增多,其抗氧化和雌激素样作用对于抵抗绝经后骨流失的效果显著。本文通过查阅国内外文献,对氧化应激介导绝经后骨质疏松发病机制进行阐述,并对中药活性成分抗氧化防治绝经后骨质疏松作用的研究进展进行综述。

Postmenopausal osteoporosis is mainly due to the imbalance of bone metabolism mediated by estrogen reduction.Studies have shown that oxidative stress is an important pathogenesis of this disease.Oxidative stress and estrogen deficiency affect osteoblasts and osteoclasts,leading to an imbalance in bone remodeling.In recent years,a number of studies investigated the prevention and treatment of postmenopausal osteoporosis by active ingredients of traditional Chinese medicine has been made,and its antioxidant and estrogen-like effects have significant effects on resisting postmenopausal bone loss.By reviewing international and domestic literature,this paper summarizes the pathogenesis of oxidative stress-mediated postmenopausal osteoporosis,and reviews the research progress of the anti-oxidation effect of active ingredients of traditional Chinese medicine in preventing and treating postmenopausal osteoporosis..