稳心颗粒联合胺碘酮治疗老年慢性心力衰竭合并心房颤动的效果

Effect of Wenxin Granules combined with Amiodarone in the treatment of chronic heart failure with atrial fibrillation in the elderly

目的探讨稳心颗粒联合胺碘酮治疗老年慢性心力衰竭(CHF)合并心房颤动的效果。方法选取2017年2月—2019年9月四川绵阳四〇四医院收治的106例CHF合并心房颤动患者,并按随机数字表法将其分为对照组和研究组,每组各53例。对照组予以胺碘酮治疗,研究组增加稳心颗粒治疗。比较两组疗效、心功能指标、相关血清指标变化情况及治疗期间发生的不良反应。结果研究组治疗后的临床总有效率高于对照组(P<0.05)。治疗后,两组左心室射血分数、心脏指数较治疗前升高,且研究组高于对照组(P<0.05)。治疗后,两组左心室舒张末期内径、左心室收缩末期内径、C反应蛋白(CRP)、胱抑素(CysC)、内皮素-1(ET-1)、脑钠肽(BNP)较治疗前下降,且研究组低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论稳心颗粒联合胺碘酮治疗老年CHF合并心房颤动的效果确切,可有效改善患者心功能及血清CysC、BNP、CRP、ET-1水平,且安全性较好。

Objective To investigate the effect of Wenxin Granules combined with Amiodarone in the treatment of chronic heart failure(CHF)with atrial fibrillation in the elderly.Methods A total of 106 CHF patients with atrial fibrillation admitted to Sichuan Mianyang 404 Hospital from February 2017 to September 2019 were selected and divided into control group and study group by random number table method,with 53 cases in each group.Patients in the control group were treated with Amiodarone,while the study group was added with Wenxin Granules.The efficacy,cardiac function index,related serum indexes and adverse reactions during treatment were compared between the two groups.Results After treatment,the total clinical effective rate of the study group was higher than the control group(P<0.05).After treatment,left ventricular ejection fraction and cardiac index in two groups were higher than before treatment,and those in the study group were higher than those in the control group(P<0.05).After treatment,left ventricular end diastolic diameter,left ventricular end systolic diameter,C-reactive protein(CRP),cystatin(CysC),endothelin-1(ET-1),and brain natriuretic peptide(BNP)in the two groups decreased compared with those before treatment,and those in the study group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Wenxin Granules combined with Amiodarone in the treatment of CHF with atrial fibrillation in the elderly has definite curative effect.It can effectively improve the cardiac function and serum CysC,BNP,CRP and ET-1 levels,and has a good safety.