紫丹银屑胶囊联合雷公藤多苷治疗寻常性银屑病的临床研究

Clinical effect of Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris

目的探讨紫丹银屑胶囊联合雷公藤多苷治疗寻常性银屑病的临床效果。方法选择2018年1月—2020年1月青海红十字医院收治的100例寻常性银屑病患者,按随机数字表法将其分为对照组(50例)和观察组(50例)。对照组采用雷公藤多苷治疗,观察组给予紫丹银屑胶囊联合雷公藤多苷治疗,两组均连续给予治疗12周。治疗后进行临床疗效评价。比较两组治疗前后的银屑病皮损面积及严重程度指数(PASI)评分、视觉模拟评分(VAS)、皮肤病生活质量指数(DLQI)评分、胎盘钙黏素(P-cad)、Trappin-2、中性粒细胞蛋白酶(NE)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)水平。比较两组治疗过程中的不良反应。结果观察组临床总有效率高于对照组(P<0.05)。治疗后,两组PASI、VAS及DLQI评分,皮损组织液中P-cad、Trappin-2及NE水平均低于治疗前(P<0.05),且观察组PASI、VAS及DLQI评分,皮损组织液中P-cad、Trappin-2及NE水平低于对照组(P<0.05)。治疗后,两组血清GSH-Px、SOD水平均高于治疗前(P<0.05),且观察组血清GSH-Px、SOD水平高于对照组(P<0.05)。两组治疗期间不良反应发生率比较差异无统计学意义(P>0.05)。结论紫丹银屑胶囊联合雷公藤多苷治疗寻常性银屑病具有显著的效果,可明显改善患者的临床症状,减轻皮损程度,提高患者生活质量,下调皮损组织液中P-cad、Trappin-2及NE水平,上调血清GSH-Px、SOD水平,且安全性较好。

Objective To investigate the clinical efficacy of Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris.Methods From January 2018 to January 2020,a total of 100 psoriasis vulgaris patients admitted to Qinghai Red Cross Hospital were selected and divided into control group(50 cases)and observation group(50 cases)by random number table method.The control group was treated with Tripterygium wilfordii multiglucoside,while the observation group was treated with Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside.The two groups were treated for 12 weeks.The clinical efficacy was evaluated after treatment.The psoriasis area and severity index(PASI)scores,visual analog score(VAS),dermatology life quality index(DLQI)scores,P-cadherin(P-cad),Trappin-2,neutrophils protease(NE),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)of the two groups were compared before and after treatment.The adverse reactions during treatment were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group(P<0.05).After treatment,the scores of PASI,VAS and DLQI,the P-cad,Trappin-2 and NE levels in the lesional tissue fluid in the two groups were lower than those before treatment(P<0.05),and the scores of PASI,VAS and DLQI,the P-cad,Trappin-2 and NE levels in the lesional tissue fluid in the observation group were lower than those in the control group(P<0.05).After treatment,the serum GSH-Px and SOD levels in the two groups were higher than those before treatment(P<0.05),and serum GSH-Px and SOD levels in the observation group were higher than those in the control group(P<0.05).There was no significant difference in adverse reactions incidence between the two groups during the treatment(P>0.05).Conclusion Zidan Yinxie Capsules combined with Tripterygium wilfordii multiglucoside in the treatment of psoriasis vulgaris has significant effect.It can significantly improve the clinical symptoms of patients,reduce the degree of skin lesions,improve the quality of life,lower the P-cad,Trappin-2 and NE levels in the lesion tissue fluid,and increase the serum GSH-Px and SOD levels,with good safety.