摘要
自身免疫性脑炎(AE)是由自身免疫机制介导的脑炎。认知障碍不仅是AE急性期的主要表现之一,在经免疫治疗或肿瘤切除后预后良好的部分AE患者的长期随访中也存在认知障碍,并且不同类型AE的急性期认知障碍及长期遗留认知障碍的比例、主要损害认知域及影响因素等各不相同。笔者现对不同类型AE的认知障碍情况进行总结,以期提高临床医生对AE认知障碍的认识。
Autoimmune encephalitis(AE)is a kind of encephalitis mediated by autoimmune mechanism.Cognitive impairment is one of the main manifestations of AE at acute phase.Cognitive impairment is also found during long-term follow-up in some AE patients who have good prognosis after immunotherapy or tumor resection.In addition,the proportion of patients with long-term cognitive impairment,main cognitive impairment domains and risk factors are different in various types of AE.This paper summarizes the cognitive impairment in different types of AE,hoping to improve the clinicians'understanding of cognitive impairment in AE.
作者
林静芳
周东
洪桢
Lin Jingfang;Zhou Dong;Hong Zhen(Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2020年第11期1170-1175,共6页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81971213、81671291)
科技部-国家重点研发计划(2018YFC1312300)。
