四川省重型/危重型新型冠状病毒肺炎患者神经系统相关症状的回顾性分析

Retrospective Analysis of Neurological Symptoms of Severe/Critical COVID-19 Patients in Sichuan Province

目的 回顾性分析四川省重型/危重型新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者的神经系统相关症状及特点.方法 纳入2020年1月11日-2020年3月20日经四川省COVID-19定点收治医院确诊的90例重型/危重型患者.回顾性分析其临床症状、检验结果、治疗方案及临床转归等.结果 90例COVID-19患者中,男性54例、女性36例,平均年龄为(53.90±16.92)岁.除经典的发热和/或呼吸系统症状外,53例患者还合并多种神经系统相关症状,包括乏力33例、肌痛21例、头晕12例、头痛8例、精神障碍3例、意识障碍1例、颈痛1例.有神经系统相关症状的患者从入院到确诊的时间较无神经系统相关症状的患者更长(P<0.05),同时接受的抗真菌治疗更多(P<0.05).结论 神经系统相关症状在四川省重型/危重型COVID-19患者中较常见,诊疗困难.

Objective To retrospectively analyze the symptoms and characteristics of nervous system damage in severe/critically severe patients with coronavirus disease 2019(COVID-19)in Sichuan province,with a view to providing basic references for the prevention and treatment of COVID-19.Methods A total of 90 patients with severe/critically severe COVID-19 were included,who were diagnosed and treated in COVID-19 designated hospital of Sichuan province from 11 January 2020 to 20 March 2020.Clinical features,test results,treatment options and clinical outcomes were analyzed retrospectively.Results Of 90 patients,there were 54 males and 36 females,with an average age of(53.90±16.92)years.In addition to the classic symptoms such as fever and/or respiratory symptoms,53 patients also had various degrees of neurologic manifestations,including 33 cases of fatigue,21 muscle soreness,12 dizziness,8 headaches,3 mental disorders,and 1 consciousness disorders and 1 case of neck pain.Compared with the patients without neurologic manifestations,those with neurologic manifestations took a longer time from admission to diagnosis of COVID-19(P<0.05),and received more antifungal treatment(P<0.05).Conclusions Neurological symptoms are not uncommon in severe/critically severe patients with COVID-19,and it’s relatively difficult in the treatment.It should be paid attention in order to avoid misdiagnosis.