糖尿病管理新策略:葡萄糖目标范围内时间

A new strategy for diabetes management:time in target range of glucose

随着我国1型和2型糖尿病的患病率逐年增加,国家对糖尿病治疗的投入不断加大,但是糖尿病患者的血糖管理确不尽如人意,以糖化血红蛋白作为评估血糖管理的指标具有一定局限性,所以探索其他有价值的评价指标尤为重要。研究发现,基于持续动态葡萄糖监测系统计算所得的指标:葡萄糖目标范围内时间,与平均血糖高度相关,且与糖化血红蛋白呈线性负相关,是评价血糖达标的关键指标。除了评估血糖波动情况,监测葡萄糖目标范围内时间可以降低1型糖尿病患者低血糖发生频率、缩短低血糖持续时间,提高1型糖尿病患者生存质量,还可用于评估2型糖尿病患者微血管及大血管并发症的发生和严重程度,对1型和2型糖尿病患者的血糖全面管理均有重要意义。因此,应大力推行动态血糖监测系统,将葡萄糖目标范围内时间及糖化血红蛋白两项指标结合起来共同评估糖尿病患者血糖管理情况,提高我国糖尿病患者血糖达标率。

In our country,the prevalence of type 1 and type 2 diabetes is increasing year by year,while the glucose management of diabetic patients is indeed not satisfactory.Glycosylated hemoglobin,as an indicator of blood glucose management,has certain limitations.So,it is particularly important to explore other valuable evaluation indicators.Some studies found that,time-in-target-range of glucose is highly correlated with average blood glucose and has a linear negative correlation with glycosylated hemoglobin.Time in range(TIR)will be a key indicator for evaluating blood glucose compliance.In addition to blood glucose assessment,monitoring TIR can also reduce the frequency and duration of hypoglycemia in type 1 diabetes patients,improving the quality of life in type 1 diabetes patients.Besides that,TIR can also be used to assess the occurrence of microvascular and macrovascular complications in type 2 diabetes patients.Therefore,TIR is important for glucose management type 1 and type 2 diabetes patients.