免疫疗法在肝细胞癌中的应用研究进展

Application of immunotherapy in hepatocellular carcinoma

肝细胞癌是重要的全球疾病负担之一,易发生转移和复发,患者病死率高,预后极差。随着免疫学、分子生物学、基因工程等技术的发展,免疫治疗在改善肝细胞癌患者预后中的表现受到广泛关注。本文总结了肝细胞癌免疫治疗的发展,阐述免疫治疗检查点抑制剂在肝细胞癌中的应用价值及局限性,同时总结性地提出免疫治疗进一步应用的可能发展方向。

Hepatocellular carcinoma is one of the important global disease burdens,which is prone to metastasis and recurrence,with highly mortality rate and poor prognosis.Under the development of immunology,molecular biology,genetic engineering and other technologies,the performance of immunotherapy in improving the prognosis of patients with hepatocellular carcinoma has received widespread attention.This article summarizes the development of immunotherapy for hepatocellular carcinoma,expounds the application value and limitations of immunotherapy checkpoint inhibitors(ICIs)in hepatocellular carcinoma,and summarizes the possible development directions for further application of immunotherapy.