N^6-甲基腺苷修饰在肝病中的作用研究进展

Research progress of the role N6-methyladenosine modificationin in liver disease

N^6-甲基腺苷(m^6A)修饰是存在于各类真核生物中最广泛、最稳定、最保守的mRNA修饰方式。它由甲基化酶引入,去甲基化酶去除,甲基化修饰结合蛋白识别。肝脏是最大的消化及代谢器官,m^6A修饰在生理性肝脏功能及各类病理性肝病中发挥着独特的作用。本文就近年来m^6A修饰在常见性肝病(如病毒性肝炎、非酒精性脂肪性肝病、肝细胞癌、肝母细胞瘤等)中的生物学作用研究进展进行综述,并讨论了m^6A修饰作为潜在干预靶点在这些疾病治疗中的意义。

N^6-methyladenosine(m^6A)modification is the most extensive,stable and conservative mRNA modification in all kinds of eukaryotes.It is introduced by methylase,removed by demethylase,and recognized by methylated modified binding proteins.Liver is the largest digestive and metabolic organ.m^6A modification plays a unique role in physiological liver function and various pathological liver diseases.In this paper,recent advances in the biological role of m^6A modification in common liver diseases(such as viral hepatitis,non-alcoholic fatty liver disease,hepatocellular carcinoma,hepatoblastoma,etc.)were reviewed,and the potential therapeutic strategy of m^6A modification in these liver diseases was discussed.