摘要
黄酮物质广泛存在于陆生植物中,是药用植物中一类重要的活性物质。黄芩的主要活性成分黄芩素、汉黄芩素及其糖苷黄芩苷、汉黄芩苷,是一类重要的黄酮,它们可以诱导多种癌细胞系的凋亡,同时具有抗氧化、抗病毒和肝脏保护等药理活性。近年来,人们对黄芩属植物黄酮生物合成机制进行了深入的研究,解析了黄芩中黄芩素和汉黄芩素的生物合成途径。该文综述了黄芩属植物黄酮的生物合成、环境因子和诱导子对黄酮合成的调控,以及黄酮合成的代谢工程。
Flavones are widely distributed in terrestrial plants and act as important bioactive compounds in medicinal plants. Baicalein, wogonin and their glycosides baicalin and wogonoside are major active components found in medicinal plant Scutellaria baicalensis. These flavones can induce apoptosis in various cancer cell lines, with such pharmacological activities as anti-oxidation, antivirus and liver protection. In recent years, the biosynthesis pathways of flavones in Scutellaria have been studied thoroughly. In particular, the biosynthesis pathways of baicalein and wogonin in S. baicalensis were interpreted completely. In this review, the biosynthesis of flavones in Scutellaria, the regulation of environmental factors and elicitors on their biosynthesis, and the metabolic engineering of the flavones were discussed.
作者
方誉民
崔孟颖
柳洁
裴天林
魏宇昆
赵清
FANG Yu-min;CUI Meng-ying;LIU Jie;PEI Tian-lin;WEI Yu-kun;ZHAO Qing(Shanghai Key Laboratory of Plant Functional Genomics and Resources,Shanghai Chenshan Botanical Garden,Shanghai Chenshan Plant Science Research Center,Chinese Academy of Sciences,Shanghai 201602,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第20期4819-4826,共8页
China Journal of Chinese Materia Medica
基金
国家重点研发计划项目(2018YFC1706202)
国家自然科学基金项目(31700268,31870282)
上海市绿化和市容管理局辰山专项(G182401,G192419)
中国科学院青年创新促进会项目。
关键词
黄芩属
黄酮
生物合成
调控
诱导子
代谢工程
Scutellaria
flavone
biosynthesis
regulation
elicitor
metabolic engineering