芪胶升白胶囊联合化疗对直肠癌造口术后骨髓抑制和免疫调节的影响

Effect of Qijiao Shengbai Capsule Combined with Chemotherapy on Myeloid Suppression and Immune Regulation after Rectal Cancer Ostomy

目的观察芪胶升白胶囊联合化疗对直肠癌造口术后骨髓抑制和免疫调节的影响。方法选取我院直肠癌造口术患者92例作为研究对象,分为观察组与对照组各46例。对照组采用单纯化疗进行治疗,观察组在对照组治疗基础上加服芪胶升白胶囊进行治疗,比较两组患者总有效率、骨髓抑制的发生率和程度、外周辅助性T细胞-17(Th17)、白介素(IL-17、IL-23)的水平。结果观察组总有效率89.13%(41/46)高于对照组60.87%(28/46)(P<0.05)。观察组骨髓抑制发生率63.04%低于对照组80.43%(P<0.05),观察组骨髓抑制程度(0度17例,度16例,Ⅱ度8例,Ⅲ度5例)较对照组明显减轻(0度9例,Ⅰ度18例,Ⅱ度14例,Ⅲ度5例)(P<0.05)。治疗前两组Th17、IL-17和IL-23的水平差异无统计学意义(P>0.05),治疗后两组Th17、IL-17和IL-23均下降(P<0.05)且观察组Th17、IL-17和IL-23均低于对照组(P<0.05)。结论芪胶升白胶囊联合化疗对直肠癌造口术后化疗患者的疗效较好,降低骨髓抑制的发生率及严重程度,改善免疫功能。

Objective To observe the effect of Qijiao Shengbai Capsule combined with chemotherapy on bone marrow suppression and immunoregulation after rectal cancer ostomy.Methods A total of 92 patients with ostomy of rectal cancer were selected as the research objects,and they were divided into observation group and control group with 46 cases each.Control group was treated with chemotherapy alone,and observation group was treated with Qijiao Shengbai Capsule on the basis of control group.The total effective rate,incidence and degree of bone marrow suppression,peripheral helper T cells-17(Th17),and interleukin-17(IL-17)IL-23 were compared between the two groups.Results The total effective rate in observation group was 89.13%(41/46)higher than that in control group 60.87%(28/46)(P<0.05).The incidence of bone marrow suppression in the observation group was 63.04%(29/46)lower than that in control group by 80.43%(37/46).The degree of bone marrow suppression in observation group(17 cases at 0 degrees,16 cases atⅠdegrees,8 cases atⅡdegrees,and 5 cases atⅢdegrees)was significantly reduced compared with the control group(9 cases at 0 degrees,18 cases atⅠdegrees,14 cases atⅡdegrees,and 5 degrees atⅢdegrees)(P<0.05).There was no significant difference in the levels of Th17,IL-17 and IL-23 in the two groups before treatment(P>0.05),Th17,IL-17 and IL-23 in the two groups decreased after treatment(P<0.05);Th17,IL-17 and IL-23 in observation group were lower than those in control group(P<0.05).Conclusion Qijiao Shengbai Capsule combined with chemotherapy has better curative effect on patients undergoing postoperative chemotherapy for rectal cancer,reducing the incidence and severity of bone marrow suppression and improving immune function.