谷氨酸棒杆菌中氨基酸分泌转运蛋白及其代谢改造研究进展

Amino acid exporters and metabolic modification of Corynebacterium glutamicum—a review

氨基酸是一类在食品、医药及化工等领域具有广泛应用的重要化合物。谷氨酸棒杆菌Corynebacterium glutamicum是生物合成氨基酸最重要的微生物菌株,其年产各类氨基酸超过百万吨。谷氨酸棒杆菌高产氨基酸除具有强大的合成代谢能力外,高效的分泌转运能力也是不可忽略的分子基础。文中综述了近年来谷氨酸棒杆菌中氨基酸分泌转运蛋白及其代谢改造的研究进展,并展望了未来发展方向,为进一步改造提升其发酵生产氨基酸的能力提供了可资借鉴的资料。

Amino acids are important compounds with a wide range of applications in the food,medicine and chemical industries.Corynebacterium glutamicum is a powerful workhorse commonly used in industrial amino acid production,with the scale of more than one million tons.In addition to its efficient anabolism,the effective exporters also ensure the high amino acid production by C.glutamicum.In this review,the research progress of amino acid exporter of C.glutamicum is summarized,to provide the foundation for further improving amino acid production by C.glutamicum via metabolic engineering.