重组人干扰素α-2b联合利巴韦林对流行性腮腺炎患儿临床症状及炎症反应的影响

Effect of recombinant human interferon α-2b combined with Ribavirin on clinical symptoms and inflammatory response in children with mumps

目的探讨重组人干扰素α-2b联合利巴韦林对流行性腮腺炎患儿临床症状及炎症反应的影响。方法选择2018年5月-2020年3月我院收治的86例流行性腮腺炎患儿作为研究对象,按照随机数字表法分为观察组与对照组,每组各43例。对照组给予利巴韦林治疗,在对照组基础上观察组加用重组人干扰素α-2b治疗,2组均连续治疗5d。对比2组临床症状消失时间与不良反应发生率,并比较治疗前与治疗5d后炎症因子水平。结果观察组发热消失时间、腮腺肿胀消失、腮腺疼痛消失时间均较对照组短,差异显著(P<0.05);治疗5d后,2组可溶性白介素-2受体(SIL-2R)、白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)水平均较治疗前低,且观察组患儿更低,差异显著(P<0.05);观察组不良反应总发生率较对照组略高,但差异不显著(P>0.05)。结论流行性腮腺炎患儿采用重组人干扰素α-2b与利巴韦林联合治疗的临床效果显著,不仅能够缩短症状消失时间,还可减轻炎症反应,且不良反应未明显增加。

Objective To investigate the effect of recombinant human interferon α-2b combined with ribavirin on clinical symptoms and inflammatory response of children with mumps.Methods 86 cases of mumps children in our hospital from May 2018 to March 2020 were selected as the research objects,and they were randomly divided into observation group and control group,43 cases in each group.The control group was treated with ribavirin,and the observation group was treated with recombinant human interferon α-2b on the basis of the control group.Both groups were treated for 5 days.The disappearance time of clinical symptoms and the incidence of adverse reactions were compared between the control group and the observation group,and the inflammatory reaction before and after 5 days of treatment were compared.Results The disappearance time of fever,parotid gland swelling and parotid pain in the observation group were shorter than those in the control group(P<0.05);after 5 days of treatment,the levels of soluble interleukin-2 receptor(sIL-2R),interleukin-6(IL-6)and tumor necrosis factor(TNF-α)in the two groups were lower than those before treatment,and the observation group was lower,with significant difference(P<0.05);adverse:reactions in the observation group were significantly lower than those in the control group(P<0.05)The total incidence of stress was slightly higher than that of the control group,but the difference was not significant(P>0.05).Conclusion the clinical effect of recombinant human interferon α-2b combined with ribavirin in the treatment of children with mumps is significant,which can not only shorten the disappearance time of symptoms,but also reduce the inflammatory reaction,with less adverse reactions and certain safety.