Idelalisib的严重不良反应及临床处理概述

Clinical Treatment of Idelalisib-Associated Severe Adverse Reactions

Idelalisib是用于治疗恶性血液病的选择性磷脂酰肌醇-3-激酶$亚型抑制药。尽管它在临床上有显著疗效,但是严重药品不良反应必须高度关注。本文描述了该药相关的肝毒性、腹泻或肠炎、肺炎和感染等严重不良反应,提供了临床诊断和处理的指南。

Idelalisib is a selective inhibitor of the delta isoform of phosphoinositide 3-kinase(PI3K)for the treatment of hematological malignancy.There is much concern about the drug-induced severe adverse drug reactions(ADRs)although idelalisib demonstrated its significant efficacy in clinical practice.This review presented ADRs associated with idelalisib such as severe diarrhea and colitis,hepatotoxicity,pneumonitis and infection,and provided clinical guideline for the identification and management of associated with idelalisib therapy.