长链非编码RNA(lncRNA)在骨关节炎中的研究进展

Research progress on long non-coding RNA(lncRNA)in osteoarthritis

骨关节炎(osteoarthritis,OA)是临床上的常见病,发病率随年龄的增长显著增加,患者的生活质量受到严重影响。在OA的发病过程中,软骨退行性病变是主要病因。在骨关节炎中有很多特异性表达的长链非编码RNA(long non-coding RNA,lncRNA),并与骨关节炎的发生、发展有着密切的关系。本文通过查阅2014年至2019年最新研究为基础,对lncRNA在骨关节炎中的差异性表达、lncRNA调控软骨细胞功能的机制、lncRNA对软骨基质代谢的机制予以总结,在OA进展的不同阶段识别出lncRNA的表达改变的事实表明lncRNA可以被开发为生物标志物和治疗靶点,为骨关节炎的预防和治疗及研究提供参考。

Osteoarthritis(OA)is a common clinical disease.The incidence of OA increases significantly with age,and the quality of life of patients is seriously affected.In the pathogenesis of OA,cartilage degeneration is the main cause.There are many long non-coding RNA(lncRNA)specifically expressed in osteoarthritis,which is closely related to the occurrence and development of osteoarthritis.Based on the latest research from 2014 to 2019,this paper summarizes the differential expression of lncRNA in osteoarthritis,the mechanism of lncRNA regulating chondrocyte function,and the mechanism of lncRNA regulating cartilage matrix metabolism.The fact that the expression of lncRNA is altered at different stages of OA development indicates that lncRNA can be developed for life.The biomarkers and therapeutic targets can provide reference for the prevention,treatment and research of osteoarthritis.