结节性类天疱疮一例并文献复习

Pemphigoid nodularis:a case report and literature review

报道1例结节性类天疱疮并复习相关文献。患者,女,62岁。全身反复出现丘疹、结节伴瘙痒10年。查体:躯干、四肢可见暗红色丘疹、结节、斑块,未见水疱。实验室检查:IgE明显升高。组织病理示:表皮角化过度、角化不全,棘层增厚,真皮浅层血管周围轻度单一核细胞浸润。直接免疫荧光和间接免疫荧光均阴性。血清学检查示:抗BP180抗体>200 U/mL(0~20 U/mL)。诊断为结节性类天疱疮。予泼尼松、环磷酰胺治疗,继续随访中。

A case of pemphigoid nodularis is reported and relative literature is reviewed.A 62-year-old female presented with papules and nodules all over the body with itching for 10 years.Physical examination showed dark red papules,nodules and plaques on the trunk and limbs and no visible blister was seen.The level of IgE in blood was increased.Histopathological examination showed hyperkeratosis or parakeratosis of epidermis,acanthosis,perivascular mononuclear cells infiltration in the superficial dermis.Direct immunofluorescence and indirect immunofluorescence were negative.Anti-BP180 IgG titres were above 200 U/mL.The diagnosis of pemphigoid nodularis was made.Prednison and cyclophosphamide were given,and the patient is under follow-up.