ABO血型与冠心病的相关性研究

The relationship of ABO blood group and coronary artery disease

目的研究ABO血型是否与冠心病发生存在相关性。方法采集2017年1月至2018年2月入住扬州大学附属医院心血管内科的986例疑似冠心病的病人,每例病人行冠状动脉造影检查。按造影检查的结果分为两组,即冠心病组(730例)和非冠心病组(对照组,256例),按血型检测结果分为A型组(341例)和非A型组(645例),O型组(282例)和非O型组(704例),研究ABO血型是否与冠心病发生存在相关性。结果986例病人中,A型血的病人冠心病发病率(80.1%)相对于非A型血的病人显著增高(70.9%)(P<0.05);O型血组冠心病的发病率(68.4%)显著低于非O型血组(76.3%)(P<0.05)。logistic多元回归分析结果提示A血型是影响冠心病发生的独立危险因素(OR=1.52,95%CI:1.08~2.13,P<0.05)。结论ABO血型与冠心病的发病率存在相关性,A血型是冠心病的独立危险因素。

Objective To analyze the correlation between ABO blood group and the incidence of coronary artery disease(CAD).Methods Data of 986 patients with suspected coronary heart disease admitted to Department of Cardiology,The Affiliated Hospi⁃tal of Yangzhou University from January 2017 to February 2018 were collected.All patients underwent coronary angiography,and were assigned into CAD group(n=730)and non⁃CAD group(control group,n=256)according to angiographic findings.Accord⁃ing to ABO blood group,patients were assigned into A blood group(n=341)and non⁃A blood group(n=645),as well as O blood group(n=282)and non⁃O blood group(n=704).The association of ABO blood group and CAD was explored.Results In 986 patients,the incidence rate of coronary heart disease patients with A blood type was significantly higher than that with non⁃A blood type(80.1%vs.70.9%,P<0.05),and the incidence rate of coronary heart disease patients with O blood type was significantly low⁃er than that with non⁃O blood type(68.4%vs.76.3%,P<0.05).Logistic multiple regression analysis showed that blood type A was an independent risk factor for coronary heart disease(OR=1.52,95%CI:1.08⁃2.13,P<0.05).Conclusion ABO blood group is closely related to the occurrence of CAD,and type A blood group is an independent risk factor for CAD.