鳖甲化纤汤联合拉米夫定治疗乙型肝炎患者34例

Treatment of 34 Cases of Hepatitis B with Lamivudine Combined with Biejia Huaxian Decoction

目的:探究鳖甲化纤汤联合拉米夫定治疗乙型肝炎患者的临床效果。方法:选取2013年2月-2016年5月本院68例乙型肝炎患者,随机数字表法分组,各34例。常规组予以拉米夫定治疗,于此基础上,观察组予以鳖甲化纤汤治疗。观察两组治疗效果,并对比治疗前后两组肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)及谷氨酰转肽酶(GGT)]、氧化应激(SOD、MDA)、炎性因子(IL-6、TNF-α)水平。结果:观察组治疗总有效率94.12%(32/34),远高于常规组的67.65%(23/34),差异有统计学意义(P<0.05);观察组治疗前肝功能指标与常规组相比,差异无统计学意义(P>0.05);与常规组相比,观察组治疗后AST、ALT及GGT水平均较低,差异有统计学意义(P<0.05);治疗后观察组血清SOD、MDA水平优于常规组,血清IL-6、TNF-α水平低于常规组(P<0.05)。结论:对乙型肝炎患者予以鳖甲化纤汤配合拉米夫定治疗,可促进患者肝功能恢复,改善机体氧化应激、炎性反应状态,效果较为显著。

Objective:To investigate the clinical efficacy of Lamivudine combined with Biejia Huaxian Decoction in the treatment of hepatitis B.Method:A total of 68 patients with hepatitis B in our hospital from February 2013 to May 2016 were selected and grouped by random number table method,34 cases each.The conventional group received Lamivudine treatment,and on this basis,the observation group received Biejia Huaxian Decoction.The therapeutic effects of the two groups were observed,and the liver function indexes[aspartate aminotransferase(AST),alanine aminotransferase(ALT)and glutamyl transpeptidase(GGT)],oxidative stress(SOD,MDA),and inflammatory factors(IL-6,TNF-α)before and after treatment were compared between the two groups.Result:The total effective rate of treatment in the observation group was 94.12%(32/34),which was much higher than 67.65%(23/34)in the conventional group,and the difference was statistically significant(P<0.05).There was no significant difference in liver function between the observation group and the conventional group before treatment(P>0.05).Compared with the conventional group,AST,ALT and GGT levels were lower in the observation group after treatment,with statistically significant differences(P<0.05).After treatment,the serum SOD and MDA levels of the observation group were better than those of the conventional group,and the serum IL-6 and TNF-αlevels were lower than the conventional group(P<0.05).Conclusion:Hepatitis B patients treated with Biejia Huaxian Decoction combined with Lamivudine treatment can promote the recovery of liver function,improve the body’s oxidative stress and inflammatory response,and the effect is more significant.