慢性阻塞性肺疾病相关性衰弱发病机制及营养干预的研究进展

Recent Advances in Pathogenesis and Nutrition Interventions of Frailty in Chronic Obstructive Pulmonary Disease

随着全球人口老龄化,衰弱作为一种老年综合征,近年来受到老年医学领域研究者的广泛关注。慢性阻塞性肺疾病是衰弱的高危因素之一,因此,慢性阻塞性肺疾病相关性衰弱也成为许多研究探讨的热点。但是众多研究主要致力于慢性阻塞性肺疾病中衰弱发生率的横断面调查以及对两者相关性的探讨,对于其发病机制及干预措施的研究论述较为分散,综述类文献相对缺乏。而且,深入研究此类患者的发病机制和探讨有效干预措施对于改善患者的长期生存质量又极其必要,因此,本文结合有关的研究近况对其发病机制进行阐述,并对相关的营养干预措施进行综述,旨在为制定针对慢性阻塞性肺疾病伴发衰弱人群的营养干预方案提供参考。

With the aging of the global population,frailty,as a geriatric syndrome,has attracted extensive attention from researchers in the field of geriatrics in recent years.Since chronic obstructive pulmonary disease(COPD)is one of the high risk factors of frailty,frailty in COPD has been a research focus.However,previous studies are mainly cross-sectional investigations on the incidence of frailty in COPD and their correlations,while comprehensive studies,especially reviews on the pathogenesis and nutrition interventions of frailty in COPD are relatively lacking.Considering the importance of pathogenesis and effective nutrition interventions of frailty in improving the long-term life quality of COPD patients,we reviewed relevant advances that have been recently achieved,aiming to provide a reference for the development of nutrition intervention programs targeting population with COPD with frailty.