摘要
糖尿病肾病(diabetic kidney disease,DKD)作为糖尿病最主要的并发症之一,是全球糖尿病患者心血管疾病发病率和病死率上升的主要原因。与长链非编码RNA(lncRNA)转移相关的肺腺癌转录本1(MALAT1)是与DKD相关的新型lncRNA,其在DKD发生、发展中的作用一直受众多学者关注。MALAT1在DKD中高表达,其可通过调节下游相关靶基因的表达或介导相关信号通路的活性,在DKD的发生发展进程中起着关键作用。MALAT1有望成为DKD治疗的新靶点。本文对MALAT1在DKD的相关性研究进行了综述。
Diabetic kidney disease(DKD),as one of the most important complications of diabetes,has been increasing worldwide,which is the main cause of cardiovascular disease and mortality in patients with DKD.The long noncoding RNA(Lnc RNA)transfer related lung adenocarcinoma transcript 1(MALAT1)is a new type of Lnc RNA related to DKD,and its role in the genesis and development of DKD has always been the focus of many scholars.Lnc RNA MALAT1 is highly expressed in DKD,which plays a key role in the development of DKD by regulating the expression of downstream related target genes or mediating the activity of related signal pathways.MALAT1 is expected to be a new target of DKD treatment.In this paper,the correlation of MALAT1 in DKD is reviewed.
作者
常微微
张留
姚新明
金岳龙
姚应水
CHANG Wei-wei;ZHANG Liu;YAO Xin-ming;JIN Yue-long;YAO Ying-shui(School of Public Health,Wannan Medical College,Wuhu 241002,Anhui Province,China;Wuhu Hospital of Traditional Chinese Medicine,Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Wuhu 241000,Anhui Province,China;Department of Endocrine,Yijishan Hospital,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,Anhui Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2020年第21期3530-3532,3537,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(82003546)
高校优秀青年人才支持计划重点基金资助项目(gxyqZD2017066,gxyqZD2017035)
安徽省自然科学基金资助项目(1808085MH297)。
关键词
糖尿病肾病
长链非编码RNA
肺腺癌转移相关转录本1基因
靶基因
diabetic kidney disease
long-chain noncoding RNA
metastasis associated lung adenocarcinoma transcript 1
target gene