局部进展小细胞肺癌靶区勾画放疗的效果及对患者生存质量的影响

Study of Effect of Radiotherapy Target Area Delineation for Locally Advanced Small Cell Lung Cancer and its Impact on Patients'Quality of Life

目的探讨局部进展小细胞肺癌靶区勾画放疗的效果及对患者生存质量的影响。方法选取局部进展小细胞肺癌患者70例,按照随机数字法分为研究组和对照组,对照组应用常规放射治疗方式,研究组应用靶区勾画的放疗方式。观察比较2组患者的总生存率、局部复发率、不良反应的发生率以及生存质量的差异。结果总生存率方面,研究组患者1、3、5年的总生存率明显高于对照组患者(P<0.05)。不良反应方面,研究组患者放射性食管炎、放射性肺炎、血液学毒性等发生率明显低于对照组患者(P<0.05)。局部复发率方面,研究组患者第1年、第3年、第5年的局部复发率明显低于对照组患者(P<0.05)。生存质量方面,研究组患者进行放疗后生存质量明显高于对照组患者(P<0.05)。结论局部进展小细胞肺癌应用靶区勾画的方式放疗能够明显提高患者的总生存率,降低不良反应发生率,提高患者的局部区域控制率,进而提高患者的生存质量,值得在临床上推广应用。

Objective To explore the effect of locally advanced small cell lung cancer target area outline radiotherapy and its impact on the quality of life of patients.Methods 70 patients with locally advanced small cell lung cancer were selected and divided into the research group and the control group according to the random number method.The control group used conventional radiotherapy and the research group applied radiotherapy outlined in the target area.Observe and compare the differences in overall survival rate,local recurrence rate,incidence of adverse reactions,and quality of life between the 2 groups.Results In terms of overall survival,the 1-,3-,and 5-year overall survival rates of the study group were significantly higher than those of the control group(P<0.05).In terms of adverse reactions,the incidence of radiation esophagitis,radiation pneumonia,and hematological toxicity in the study group was significantly lower than that of the control group(P<0.05).The 1-,3-,and 5-year local recurrence rates in the study group were significantly lower than those of the control group(P<0.05).The quality of life of patients in the study group after radiotherapy was significantly higher than that of the control group(P<0.05).Conclusion Locally progressed small cell lung cancer using target area outline radiotherapy can significantly improve the patient's overall survival rate,reduce the incidence of adverse reactions,improve the patient's local regional control rate,and thus improve the patient's quality of life,which is worthy of clinical application.