肺癌骨转移患者严重程度与骨标志物水平相关性的临床研究

Clinical study of relationship of severity and bone markers in patients with bone metastasis of lung cancer

目的探讨肺癌骨转移患者严重程度与骨标志物水平相关性的临床研究。方法分析114例肺癌和70例肺部良性疾病患者血清25羟基维生素D3[25(OH)Vitamin D3,25(OH)D3]、总I型胶原氨基端延长肽(total procollagen type I aminoterminal propeptide,TPINP)和I型胶原羟基端肽β特殊序列(βisomer of C-terminal telopeptide,β-CTX)水平;生化法测定血钙水平,并进行对比性分析。结果肺癌患者血清25(OH)D3、TPINP和β-CTX水平较之肺部良性疾病患者分别为明显降低、明显增高和明显增高,与病理类型无关;随肺癌的严重程度,血清25(OH)D3水平降低,TPINP水平和β-CTX水平增高。肺癌骨转移患者较之肺癌无骨转移患者,血清25(OH)D3水平降低,血清TPINP和β-CTX水平明显增高。肺癌骨转移患者较之无骨转移患者血钙增高、血清25(OH)D3降低。结论骨标志物水平是肺癌骨转移早期诊断和严重程度评估的有价值指标。

Objective To explore clinical study of relationship of severity and bone markers in patients with bone metastasis of lung cancer.Methods The serum 25(OH)D3,TPINP,β-CTX and Ca levels in 114 patients with lung benign disease and in 70 patients with benign lung disease were analyzed and compared for analysis.Results The serum 25(OH)D3,TPINP,and β-CTX levels in lung cancer patients were significantly lower,significantly higher,and significantly higher than those in patients with lung benign disease,regardless of pathological type.With the severity of lung cancer,the serum 25(OH)D3 levels decreased,and the levels of TPINP and β-CTX increased.Serum 25(OH)D3 levels were decreased and serum TPINP and β-CTX levels were significantly increased in patients with lung cancer with bone metastasis,compared with those without bone metastasis.In patients with lung cancer with bone metastasis,serum calcium increased and serum 25(OH)D3 decreased.Conduction Bone marker level is a valuable indicator for early diagnosis and severity assessment of bone metastasis of lung cancer.