右美托咪定辅助镇静对全身麻醉患者术后睡眠功能的影响

Effect of Dexmedetomidine on Postoperative Sleep Function in Patients with General Anesthesia

目的:探究对全身麻醉患者术后采取右美托咪定辅助镇静对患者术后睡眠功能的影响。方法:选取2018年5月至2019年5月延边大学附属医院收治的接受全身麻醉手术的患者100例作为研究对象,按照随机数字表法分为对照组和观察组,每组50例,对照组采取常规全麻方式,未镇静;观察组在对照组基础上采取右美托咪定进行镇静。采取PSQI量表、Ramsay量表对2组患者的睡眠质量和镇静效果进行评估,同时对2组不良反应进行分析。结果:2组患者在术前、术日的睡眠质量评分差异无统计学意义(P>0.05),术后4 d与出院前1 d进行测验,2组睡眠质量均较术日有一定改善,但观察组患者术后4 d与出院前1 d的睡眠质量均优于对照组患者(P<0.05)。患者在术中T1、T2、T3、T44个阶段对患者进行Ramasy评分测定,结果提示,T1阶段2组患者评分差异无统计学意义(P>0.05),T2、T3、T43个阶段,观察组患者评分显著优于对照组(P<0.05)。患者主要不良反应有心动过缓、恶心呕吐、呼吸抑制、低血压。观察组患者不良反反应发生率(10.00%)显著低于对照组(22.00%)(P<0.05)。结论:采取右美托咪定辅助镇静能够显著改善患者术后睡眠功能,提升镇静效果,减少不良反应,值得临床推广。

Objective:To explore the effect of dexmedetomidine assisted sedation on sleep function of patients after general anesthesia.Methods:A total of 100 patients undergoing general anesthesia in our hospital from May 2018 to may 2019 were selected for study.All patients were divided into control group(n=50,routine general anesthesia,no sedation)and observation group(n=50,right metomidine sedation on the basis of control group).PSQI scale and Ramsay scale were used for sleep quality and The sedative effect was evaluated and the adverse reactions were analyzed.Results:There was no significant difference in sleep quality score between the two groups(P>0.05).The sleep quality of the two groups was better than that of the control group(P<0.05).The results showed that there was no significant difference between the two groups in T1 stage(P>0.05).The patients in the observation group scored significantly better than those in the control group(P<0.05).The main adverse reactions were bradycardia,nausea and vomiting,respiratory depression and hypotension.The incidence of adverse reactions in the observation group(10.00%)was significantly lower than that in the control group(22.00%).Conclusion:Dexmedetomidine can significantly improve postoperative sleep function,improve sedation effect and reduce adverse reactions.