幽门螺旋杆菌感染与结肠息肉发生的相关性分析

Analysis of the correlation between Helicobacter pylori infection and colonic polyps

目的:探究幽门螺旋杆菌(Hp)感染与结肠息肉发生的相关性。方法:选取自2018年1月—2020年6月合肥市第一人民医院行电子结肠镜检查、内镜病理活检明确诊断为结肠息肉的患者679例,并纳入同期健康体检者473例作为正常对照。所有入组患者均完成14C-尿素呼气试验(13C-UBT)或胃镜下快速尿素酶实验,并收集Hp感染情况及结肠息肉临床特征。记录并比较各组患者的Hp感染率。结果:结肠息肉组Hp感染率高于正常组(57.3%vs 47.4%)。矫正偏倚并通过logistic回归分析得出,结肠息肉患者Hp感染发生率更高,相对感染率OR=1.33(95%CI 1.14~1.42,P=0.02)。结肠多发息肉患者Hp感染发生率为67.5%,高于单发息肉患者(57.3%),相对Hp感染发生率的OR=1.15(95%CI 1.00~1.32,P=0.05)。结肠腺瘤性息肉患者Hp感染发生率为67.5%,高于炎症性息肉患者(57.3%),相对Hp感染发生率的OR=1.47(95%CI 1.15~1.32,P=0.03)。结论:结肠息肉患者Hp感染发生率高于健康体检人群,其中结肠息肉数量多,病理为腺瘤性息肉的患者Hp感染发生率更高。

Purpose:To investigate the relationship between Helicobacter pylori(Hp)infection and colonic polyp.Methods:From January 2018 to June 2020 in Hefei First People’s Hospital,many patients were examined by electron colonoscopy,among which 679 patients were clearly diagnosed with colonic polyps by endoscopic pathological biopsy,and 473 healthy patients were classified into control group.14 C-urea breath test(13 C-UBT)or gastroscopic rapid urease test were performed in all patients.The infection rate of Hp was recorded and compared.Results:The infection rate of Hp in colon polyp group was higher than that in normal group(57.3%vs 47.4%).Logistic regression analysis showed that the incidence of Hp infection was higher in patients with colon polyps,with a relative infection rate of OR=1.33(95%CI 1.14~1.42,P=0.02).The incidence of Hp infection in patients with multiple polyps was 67.5%,which was higher than that in patients with single polyps(57.3%).The incidence of Hp infection in patients with multiple polyps was OR=1.15(95%CI 1.00~1.32,P=0.05).The incidence of Hp infection in patients with adenomatous polyps was 67.5%,which was higher than that in patients with inflammatory polyps(57.3%).The relative incidence of Hp infection was OR=1.47(95%CI 1.15~1.32,P=0.03).Conclusion:The incidence of Hp infection in patients with colonic polyps is much higher than that in healthy people.Besides,if there are a large number of colonic polyps,the incidence of Hp infection in patients with adenomatous polyps is higher.