海洋生物抗炎活性物质研究进展

Advances in anti-inflammatory bioactive substances derived from marine organisms

炎症是一种常见生理反应,在疾病的发生发展过程中具有非常重要的作用。炎症反应既具有阻止致炎因子蔓延全身和清除致炎因子、修复损伤组织和器官等积极作用,也有引发细胞和组织变性和坏死,甚至诱发某些肿瘤的潜在危害。目前临床常用的抗炎药分为甾体类和非甾体类抗炎药,它们常伴有胃肠损伤等各种副作用。海洋独特的自然环境孕育了独特而多样的抗炎活性物质,如萜类、生物碱、多糖类、多肽类、脂肪酸类和聚酮类化合物等。这些独特的抗炎活性物质因具有较好的抗炎效果和较少的副作用,从而备受关注。本文综述了近年来具有抗炎活性的海洋生物活性物质及其衍生物的研究进展。

Inflammation is a common physiological reaction which plays a key role in the occurrence and development of certain diseases.The inflammatory reaction has a positive influence on preventing inflammatory factors from spreading throughout the body,removing inflammatory mediators,and repairing damaged tissues and organs.It also offers the opportunity to cause degeneration or necrosis of cells and tissues,even inducing certain tumors.Steroidal and non-steroidal anti-inflammatory drugs derived from terrestrial organisms are used for clinical purposes,but their administration is accompanied by various side effects,such as gastrointestinal damage.The specialized marine environment creates unique and varied anti-inflammatory bioactive substances,such as terpenes,alkaloids,polysaccharides,peptides,fatty acids,and polyketides.These individualized anti-inflammatory bioactive substances have attracted considerable attention with their vast potential for improved anti-inflammatory effects and fewer possible side effects.This paper reviews recent advances in marine anti-inflammatory bioactive substances and their derivatives.