金属-有机骨架材料在多肽富集中的研究进展

Recent advances in metal-organic frameworks in polypeptide enrichment

多肽在复杂生物样品中的分离是蛋白激酶信号转导途径研究的关键一步。金属-有机骨架(MOFs)已广泛应用于样品制备,由于它们独特的性质,如大比表面积、超高孔隙率、多样化功能以及良好的化学稳定性等优点,MOFs在生物领域中的应用得到了广泛的研究。本文综述了MOFs在多肽富集中的最新进展,包括了对磷酸肽以及糖肽的富集。最后,提出了MOFs材料的应用前景以及MOFs在多肽富集中存在的挑战,为提高MOFs实际应用的可能性和多样性,仍是研究者们需要努力的方向。

The isolation of peptides in complex biological samples is a key step in the study of protein kinase signal transduction pathways.Metal–Organic Frameworks(MOFs)have been widely used in sample preparation.due to their unique properties,such as large specific surface area,ultrahigh porosity,diverse functions,and good chemical stability,MOFs applications in biological fields have been extensively studied.A review of the recent progress of MOFs in polypeptide enrichment,including the enrichment of phosphopeptides and glycopeptides.Finally,the application prospect of MOFs materials and the challenges of MOFs in polypeptide enrichment are put forward.To improve the possibility and diversity of practical application of MOFs,it is still the direction that researchers need to work hard.