基于数据挖掘的治疗遗精中成药组方规律分析

Analysis on Composition Principles of Chinese Patent Drugs for Seminal Emission by Using Traditional Chinese Medicine Inheritance System

目的运用数据挖掘分析治疗遗精中成药的组方规律。方法筛选《中国药典》和《中华人民共和国卫生部药品标准·中药成方制剂》中收录的治疗遗精的中成药,基于中医传承辅助平台(V2.5),采用改进互信息法及复杂系统熵聚类等方法对所收集中成药的组方规律进行分析。结果共收集170首处方,主治证候主要为肾阳虚证、肾精亏虚证、肾虚不固证。涉及中药242味。其中补益药出现频次最高,固涩药次之;药性中使用频率最高的为温性;药味主要为甘味,其次为辛、苦;主要归肾、肝、脾经;单味药出现频次≥20%的有19味。使用频率最高的单药为熟地黄(50.29%)。在支持度为20%、置信度为0.6的情况下,共有25个核心用药组合,34条药物间关联规则。经复杂熵聚类运算分析,得到核心药物组合10个,新处方5首。结论治疗遗精中成药的适用症候以肾阳虚证、肾精亏虚证、肾虚不固证为主;主要病机为肾虚;治法以补肾固精、益肾填髓为主,辅以益气养血法;处方多以左归丸为主方进行加减,对临床治疗遗精及新药研发具有一定参考意义。

Objective To analyze the Composition Principles of Chinese patent drugs for Seminal Emission using TCM inheritance system.Methods The Chinese patent drugs treating seminal emission in the Dictionary of Traditional Chinese Medicine Prescriptions and National Standard for Chinese Patent Drugs enacted by Ministry of Public Health of China were collected and the composing principles were analized by using revised mutual information,complex system entropy clustering and so on based on the TCM inheritance system.Results A total of 170 prescriptions were collected.The main symptoms were kidney yang deficiency,kidney essence deficiency and kidney deficiency without consolidation.242 kinds of Chinese herbs were involved,of which tonic berb was the most frequent,followed by astringent berb.The most frequently used herbs was warm nature;The main flavor was sweet,followed by pungent and bitter;It mainly belongs to kidney,liver and spleen meridians;There were 19 kinds of herbs with frequency more than 20%.The most frequently used single herb was Rehmannia glutinosa(50.29%).When the support degree was 20%and the confidence level was 0.6,there were 25 core drug combinations and 34 drug association rules.Through complex entropy cluster analysis,10 core drug combinations and 5 new prescriptions were obtained.Conclusion The syndrome of kidney yang deficiency,kidney essence deficiency and kidney deficiency are the main syndrome in the treatment of seminal emission;The main treatment methods are tonifying kidney and strengthening essence,enriching kidney essence,supplemented by strengthening qi and nourishing blood;Zuogui pill is the main prescription in the treatment of seminal emission,It has certain reference significance for clinical treatment of seminal emission and new drug research and development.