硫酸特布他林联合布地奈德雾化吸入治疗重症小叶性肺炎的疗效评价

Efficacy of Terbutaline Sulfate Combined with Budesonide Inhalation in the Treatment of Severe Lobular Pneumonia

目的研究重症小叶性肺炎经硫酸特布他林联合布地奈德雾化吸入治疗的效果。方法选择我院于2014年3月至2017年9月接诊的68例重症小叶性肺炎患者,随机均分为试验组和对照组,对照组予以左氧氟沙星治疗,试验组予以硫酸特布他林联合布地奈德治疗,分别评价试验组和对照组的治疗效果。结果试验组治疗总有效率达到88.25%,显著高于对照组的70.58%,两组间差异具有统计学意义(P<0.05)。试验组体温恢复时间(2.18±0.38)d、咳嗽消失停止时间(4.18±0.95)d、肺啰音消失时间(4.37±0.94)d、气喘消失时间(3.45±0.88)d,均显著短于对照组[(3.71±0.57)d、(6.73±1.72)d、(6.77±1.26)d、(4.83±1.17)d],两组差异均具有统计学意义(P<0.05)。治疗后试验组肺功能指标PaO2(81.62±23.49)mm Hg、PaCO2(35.43±10.19)mm Hg、a/APO2(0.42±0.17)、OI(4.35±1.04)、pH(7.31±0.02),四项肺指标均显著优于对照组的肺功能指标,组间比较差异具有统计学意义(P<0.05)。结论硫酸特布他林联合布地奈德雾化吸入用于治疗重症小叶性肺炎患者能够减轻临床症状,减短临床症状消失的时间,治疗效果良好,推荐临床上推广使用。

Objective To study the therapeutic effect of terbutaline sulfate combined with budesonide inhalation therapy for severe lobular pneumonia.Methods Sixty-eight patients with severe lobular pneumonia who were admitted to our hospital from March 2014 to September 2017 were randomly divided into an experimental group and a control group.The control group was treated with levofloxacin and the test group was treated with terbutaline sulfate combined with budesonide treatment,the therapeutic effects of the experimental group and the control group were evaluated separately.Results The total effective rate of treatment in the experimental group reached 88.25%,which was significantly higher than that in the control group(70.58%),the difference between the two groups was statistically significant(P<0.05).The temperature recovery time of the experimental group(2.18±0.38)d,the disappearance time of cough(4.18±0.95)d,the disappearance time of pulmonary rales(4.37±0.94)d,and the disappearance time of asthma(3.45±0.88)d were statistically shorter than those of the control group[(3.71±0.57)d,(6.73±1.72)d,(6.77±1.26)d,(4.83±1.17)d],and the diff erences between the two groups was statistically signifi cant(P<0.05).After treatment,the lung function indexes of the test group were PaO2(81.62±23.49)mmHg,PaCO2(35.43±10.19)mm Hg,a/APO2(0.42±0.17),OI(4.35±1.04),pH(7.31±0.02),all of which were signifi cantly better than those of the control group,with statistically signifi cant diff erence between groups(P<0.05).Conclusion Terbutaline sulfate combined with budesonide nebulized inhalation for the treatment of patients with severe lobular pneumonia can reduce the clinical symptoms and shorten the time for the clinical symptoms to disappear.The treatment eff ect is good,and it is recommended for clinical use.