痰热清注射液治疗ICU重症肺炎患者的疗效

Therapeutic Effect of Tanreqing Injection on Severe Pneumonia in ICU Patients

目的探讨痰热清注射液对ICU重症肺炎患者的治疗效果及其对炎性因子的影响。方法选择2016年1月至2018年1月鞍山市台安县恩良医院收治的56例重症肺炎患者作为研究对象,根据随机原则分为对照组和观察组,每组28例。两组患者均根据呼吸道分泌物细菌培养及药敏试验选择敏感抗生素,观察组患者在此基础上予以痰热清注射液20 mL加入到250 mL生理盐水或者葡萄糖注射液中每日1次缓慢静脉滴注,治疗1周后比较两组患者的临床疗效以及治疗前后白细胞、C反应蛋白及降钙素原的水平变化情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的白细胞、C反应蛋白及降钙素原水平均较治疗前明显改善,且观察组降低幅度较大,差异均有统计学意义(P<0.05)。结论痰热清注射液联合抗生素治疗重症肺炎患者不仅能改善患者的炎性因子,缓解临床症状,还能发挥多靶点多途径杀灭细菌的作用,减少耐药菌的产生。

Objective To investigate the therapeutic eff ect of tanreqing injection on severe pneumonia patients in ICU and its infl uence on infl ammatory factors.Methods From January 2016 to January 2018,56 patients with severe pneumonia admitted to Enliang Hospital of Taian County were selected as the research objects.They were randomly divided into control group and observation group,with 28 patients in each group.Two groups of patients were selected sensitive antibiotics according to bacterial culture of respiratory secretion and drug sensitivity test.On the basis of the observation group,20 mL tanreqing injection was added to 250 mL normal saline or glucose injection once a day for a slow quiet point.After 1 week of treatment,the clinical effi cacy of the two groups of patients and the changes in the levels of white blood cells,C-reactive protein and procalcitonin before and after treatment were compared.Results The total eff ective rate of treatment in the observation group was higher than that in the control group,and the diff erence was statistically signifi cant(P<0.05).After treatment,the levels of white blood cells,C-reactive protein,and calcitonin in the two groups were signifi cantly improved compared to before treatment,and the observation group decreased significantly,and the differences were statistically significant(P<0.05).Conclusion Tanreqing injection combined with antibiotics in the treatment of severe pneumonia can not only improve the expression of infl ammatory factors,alleviate clinical symptoms and improve curative eff ect,but also play its multi-target and multi-way bactericidal eff ect,reduce the production of drug-resistant bacteria.