人参果总皂苷在难治性颞叶癫痫治疗中的作用及其机制分析

The effect of total ginsenoside in the treatment of refractory temporal lobe epilepsy and its mechanism analysis

目的:探讨人参果总皂苷在难治性颞叶癫痫治疗中的临床疗效及其作用机制,为优化治疗提供新思路。方法:将79例难治性颞叶癫痫患者随机分为观察组和对照组,对照组根据不同发作类型选服常规抗癫痫药物治疗,观察组在对照组基础上加用人参果总皂苷制剂(振源胶囊),观察其疗效及不良反应情况。结果:观察组治疗后的癫痫发作次数明显减少,且治疗9个月、12个月后的总有效率、MMSE得分明显高于对照组,差异有统计学意义(P<0.05)。期间观察组不良反应发生率较对照组低,差异无统计学意义(P>0.05)。结论:观察组在减少患者癫痫发作次数、改善认知功能方面,效果优于对照组,且疗效随着时间延长而增加。人参皂苷通过多种机制抗惊厥、保护神经系统,在难治性癫痫的治疗中可发挥较好的作用。

Objective:This study aims to explore the clinical efficacy and mechanism of ginsenosides in the treatment of refractory temporal lobe epilepsy,and to provide new ideas for the optimization of treatment.Methods:79 patients with intractable temporal lobe epilepsy were randomly divided into observation group and control group.The control group was treated with conventional antiepileptic drugs according to different seizure types,and the observation group was given ginseng fruit saponin preparation(Zhenyuan capsule)on the basis of the control group,and the curative effect and adverse reactions were observed.Results:The number of epileptic seizures in the observation group was significantly reduced,and the total effective rate and MMSE score after 9 months and 12 months of treatment in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was not statistically significant(P>0.05).Conclusion:The effect of the observation group is better than that of the control group in reducing the number of epileptic seizures and improving cognitive function,and the curative effect increases with time.Ginsenosides can play a good role in the treatment of intractable epilepsy by anti convulsion and protecting nervous system through a variety of mechanisms.