纠正亚低温配合限制性液体复苏对腹部创伤伴失血性休克患者凝血功能的影响

Effects of correcting mild hypothermia and restricted fluid resuscitation on coagulation function in patients with abdominal trauma and hemorrhagic shock

目的:探讨纠正亚低温配合限制性液体复苏对腹部创伤伴失血性休克患者凝血功能的影响。方法:将93例腹部创伤伴失血性休克患者按照随机数字表法分为对照组(46例)和观察组(47例),对照组给予纠正亚低温配合常规液体复苏治疗,观察组给予纠正亚低温配合限制性液体复苏治疗,对比两组输液量、输血量、凝血功能[纤维蛋白原(Fib)、凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)]、死亡率和并发症发生率。结果:观察组输液量和输血量均少于对照组(P<0.05);治疗后,观察组Fib高于对照组(P<0.05),PT,APTT,TT低于对照组(P<0.05);观察组并发症总发生率低于对照组(P<0.05);两组死亡率比较差异无统计学意义(P>0.05)。结论:纠正亚低温配合限制性液体复苏可改善腹部创伤伴失血性休克患者凝血功能,减少并发症发生。

Objective:To explore effects of correcting mild hypothermia combined with restricted fluid resuscitation on coagulation function in patients with abdominal trauma and hemorrhagic shock.Methods:A total of 93 patients with abdominal trauma and hemorrhagic shock in the hospital were enrolled as study objects.According to random number table method,they were divided into control group(46 cases)and observation group(47 cases).The former was treated with correcting mild hypothermia combined with routine fluid resuscitation,while the latter was treated with correcting mild hypothermia combined with restricted fluid resuscitation.The infusion volume,blood transfusion volume,coagulation function[fibrinogen(Fib),prothrombin time(PT),activated partial thrombin time(APTT),thrombin time(TT)],mortality and incidence of complications were compared between the two groups.Results:The infusion volume and blood transfusion volume in observation group were less than those in control group(P<0.05).After treatment,Fib in observation group was higher than that in control group(P<0.05),while PT,APTT and TT were lower than those in control group(P<0.05).The total incidence of complications in observation group was lower than that in control group(P<0.05),while mortality rate was not significantly different from that in control group(P>0.05).Conclusion:Correcting mild hypothermia combined with restricted fluid resuscitation can improve coagulation function and reduce complications in patients with abdominal trauma and hemorrhagic shock.