不同卵泡期HMG促排卵疗法对多囊卵巢综合征不孕症患者妊娠效果及预后的影响分析

Comparison of the Effect and Prognosis of HMG Ovulation Induction Therapy at Different Follicular Stages in Infertile Patients with Polycystic Ovary Syndrome

目的研究对比多囊卵巢综合征不孕症患者采用不同卵泡期促性腺激素促排卵疗法的妊娠效果及预后。方法选取盘锦市中心医院2017年1月-2019年1月收治的120例多囊卵巢综合征不孕症患者,按照随机数字表法分成观察组和对照组各60例。对照组于中卵泡期实施促性腺激素促排卵治疗,观察组于早卵泡期实施促性腺激素促排卵治疗。比较两组促排卵效果、妊娠结局、治疗前后性激素水平变化情况,以Logistic分析法明确多囊卵巢综合征不孕症患者成功妊娠的影响因素。结果观察组注射促性腺激素日子宫内膜厚度以及成熟卵泡数均高于对照组,促性腺激素用量少于对照组,差异均有统计学意义(P<0.05)。治疗后观察组卵泡雌激素、黄体生成素及雌二醇水平均低于对照组,差异均有统计学意义(P<0.05)。观察组妊娠率高于对照组,早期流产率低于对照组,差异均有统计学意义(P<0.05)。Logistic分析显示:早卵泡期促性腺激素促排卵、注射促性腺激素日子宫内膜厚度及成熟卵泡数均是多囊卵巢综合征不孕症患者成功妊娠的影响因素。结论对于多囊卵巢综合征不孕症患者,采用早卵泡期促性腺激素促排卵方案的效果更好,可有效提高妊娠率,同时能够改善性激素水平。

Objective To compare the efects of different follicular gonadotropin(HMG)ovulation induction therapy on pregnancy and prognosis of PCOS infertility patients.Methods A total of 120 patients with PCOS infertility admitted to Panjin Central Hospital from January 2017 to January 2019 were included in the study.They were divided into observation group and control group according to random number table method,60 cases in each group.The control group was treated with HMG ovulation induction in the middle follicular phase,while the observation group was treated with HMG ovulation induction in the early follicular phase.The effects of ovulation induction,pregnancy outcome and changes of sex hormones before and after treatment were compared between the two groups.Logistice analysis was used to identify the influencing factors of successful pregnancy in infertile PCOS patients.Results The thickness of intrauterine membrane and the number of mature fllicles of HCG in the observation group were significantly higher than control group,while the dosage of HMG was significantly lower than control group(all P<0.05).After treatment,the levels of follicular estrogen(FSH),luteinizing hormone(LH)and estradiol in the observation group were significantly lower than those of control group(all P<0.05).The pregnaney rate of the observation group was significantly higher than control group,while the rate of early abortion was significantly lower than control group(all P<0.05).According to Logistic analysis,HMG ovulation induction in the early follicular period,intrauterine membrane thickness in the HCG day and the number of mature follicles were all influential factors for sucessful pregnancy in PCOS infertile patients.Conclusion HMG ovulation induction regimen in the early fllicular period has a better efect,can efectively improve the pregnancy rate of patients,and is beneficial to improve the level of sex hormones.