MiRNA在阿尔茨海默症发病机制中的作用

Research progress of miRNA in the pathogenesis of Alzheimer’s disease

阿尔茨海默症(Alzheimer’s disease, AD)是一种常见的神经退行性疾病。近年来,AD发病率逐年增加,且常用的抗AD药物也只能改善中、轻度AD患者的症状,并不能预防、阻止和逆转AD的发展,该疾病严重影响了患者的生活质量。MiRNAs为新发现的一类具有调控人体多蛋白基因组学的非编码RNA,在生物体的生长发育、疾病的发生发展过程中起着非常重要的作用。越来越多的研究表明miRNAs与AD的发生、发展密切相关,故本文将miRNAs在AD中的作用作一综述,重点阐述miRNAs在AD发病机制中的调节作用,以及通过调节miRNAs发挥作用的天然产物和运动干预,以期为AD的治疗提供新的思路和方向。

Alzheimer’s disease(AD) is one of the common neurodegenerative diseases. In recent years, the incidence of AD has increased year by year, and the commonly used anti-AD drugs can only improve the symptoms of patients with moderate to mild AD, and can not prevent, stop or reverse the development of AD. The disease seriously affects the quality of patients’ life. MiRNAs are a newly indentified class of noncoding RNAs that regulate human polyprotein genomics, and play a key role in the growth and development of organisms and the occurrence and development of diseases. Increasing evidence show that miRNA is closely related to AD, thus this review illustrated the research of AD and miRNAs, focusing on the regulation of miRNAs in the pathogenesis of AD, miRNAs-related natural products as well as physical exercise intervention, in order to provide new ideas and directions for the treatment of AD.