SUMO化修饰在缺血性脑损伤中的作用

The role of SUMOylation in ischemic brain injury

脑卒中是一种急性脑血管疾病,主要由于脑血管破裂或血管堵塞导致血流无法供应大脑,引起脑实质损伤。脑缺血可引起多种蛋白质翻译后修饰的改变,如磷酸化、泛素化、甲基化、乙酰化和类泛素样修饰等,这些修饰在病理生理过程中起重要作用,参与脑缺血诱导的神经损伤。SUMO化(SUMOylation)为靶蛋白与小泛素样修饰物SUMO蛋白——小泛素样相关修饰分子(small ubiquitin-related modifier)共价结合,参与转录调控、细胞信号转导等多种细胞功能调控。靶蛋白的异常SUMO化通常与癌症、心脏病、糖尿病、关节炎、退行性疾病和中风等疾病相关。其中,SUMO化稳态失衡与缺血性脑损伤密切相关。本文总结了SUMO化修饰在缺血性脑损伤中作用的相关研究进展。

Stroke is an acute cerebrovascular disease. It is caused by the rupture or blockage of cerebral blood vascular, and then the blood flow can not supply the brain, resulting in brain parenchyma damage. Cerebral ischemia can cause changes in post-translational modifications of many proteins, such as phosphorylation, ubiquitination, methylation, acetylation and ubiquitin-like modification, which play important roles in pathophysiological process and participate in the brain ischemia-induced neuronal damage. Target protein is SUMOylated by covalently conjugated with small ubiquitin-related modifier, which is involved in transcriptional regulation, cell signal transduction and other cellular function regulation. Abnormal SUMOylation of target proteins is usually associated with cancer, heart disease, diabetes, arthritis, degenerative diseases and stroke. Reportedly, the imbalance of SUMOylation homeostasis is closely related to ischemic brain injury. In this review, we summarized the research progress of the role of SUMOylation in ischemic brain injury.