静息巯基氧化酶1在肿瘤微环境中的作用研究进展

Research progress on the role of quiescin sulfhydryl oxidase 1 in tumor microenvironment

静息巯基氧化酶1(quiescin sulfhydryl oxidase 1, QSOX1)可催化自由巯基氧化形成二硫键,具有极强的氧化还原活性,对于维持细胞氧化还原平衡具有重要作用,并与细胞外基质的形成和调节有关。人类的QSOX1与恶性肿瘤(包括胰腺癌、乳腺癌和前列腺肿瘤等)的发生发展有着非常密切的关系,并可能通过调节肿瘤微环境促进肿瘤的进展。本文综述了近年来QSOX1在肿瘤发生发展过程中尤其是肿瘤微环境中的研究进展,为进一步研究QSOX1在肿瘤中的作用机制提供一定的参考。

Quiescin sulfhydryl oxidase 1(QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide. Tumor cells may take advantage of oxidative environments at different stages of tumorigenesis, but QSOX1 may also serve additional functions in tumors. As interest increases in understanding the mechanisms of tumorigenesis within the extracellular matrix and how tumor cells influence fibroblasts and other stromal cells, QSOX1 may be revealed as an important player in cancer detection and prognosis. This review discussed the recent progress of QSOX1 in tumorigenesis and tumor microenvironment. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into targeting QSOX1 with anti-neoplastic agents.