手术联合放射治疗与单纯喉部分切除术治疗喉癌的安全性及有效性对比

Comparison of the safety and effectiveness of surgery combined with radiotherapy and partial laryngectomy in the treatment of laryngeal carcinoma

目的探讨喉癌患者选用手术联合放射治疗与单纯喉部分切除术治疗的临床效果。方法 50例喉癌患者,根据随机信封法分为对照组和观察组,各25例。对照组选用单纯喉部分切除术治疗,观察组选用手术联合放射治疗。对比两组临床效果、5年内生存率、并发症发生率。结果观察组临床总有效率92.00%高于对照组的68.00%,差异有统计学意义(P<0.05)。观察组患者5年内总生存率88.00%高于对照组的60.00%,差异有统计学意义(P<0.05)。观察组并发症发生率12.00%低于对照组的40.00%,差异有统计学意义(P<0.05)。结论将手术联合放射治疗应用于喉癌治疗中,能够降低并发症发生率,提高5年内生存率,改善治疗效果,安全性更高。

Objective To discuss the clinical effect of surgery combined with radiotherapy and partial laryngectomy in the treatment of laryngeal carcinoma. Methods A total of 50 patients with laryngeal carcinoma were divided into control group and observation group according to random envelope method, with 25 cases in each group. The control group was treated with partial laryngectomy, and the observation group was treated with surgery combined with radiotherapy. The clinical effect, 5-year survival rate and incidence of complications were compared between the two groups. Results The total clinical effective rate 92.00% of the observation group was higher than 68.00% of the control group, and the difference was statistically significant(P<0.05). The 5-year survival rate 88.00% of the observation group was higher than 60.00% of the control group, and the difference was statistically significant(P<0.05). The incidence of complications 12.00% of the observation group was lower than 40.00% of the control group, and the difference was statistically significant(P<0.05). Conclusion Surgery combined with radiotherapy can lower the incidence of complications, improve 5-year survival rate of patients with laryngeal carcinoma, with higher safety.