代谢组学在肾脏疾病中的研究进展

Research progress of metabolomics in kidney disease

目前肾脏疾病的准确诊断最终仍需要肾穿刺活检技术。代谢组学可以定性和定量分析生物机体包括系统、器官或细胞在受到外界因素影响下引起的内源性代谢产物的变化;肾脏疾病的发生发展会受到生物体内外多种因素的影响,与机体代谢异常密切相关,表现为各类代谢产物的变化。近年来,代谢组学为肾脏疾病的研究做出了很多贡献,本文就代谢组学在肾脏疾病中的研究进展作以综述,希望为肾脏病发生发展及诊断提供新的研究思路和方向。

At present,accurate diagnosis of kidney disease still needs renal biopsy technology.Metabolomics can qualitatively and quantitatively analyze changes in endogenous metabolites of biological organisms including systems,organs or cells under the influence of external factors.The occurrence and development of kidney diseases will be affected by various factors in and outside the organism,and is closely related with the body metabolic abnormalities,manifested as changes in various metabolites.In recent years,metabolomics has made a lot of contributions to the research of kidney disease.This article reviews the research progress of metabolomics in kidney disease,hoping to provide new research ideas and directions for the development and diagnosis of kidney disease.