甲型、丙型及戊型肝炎病毒感染性克隆的研究进展

Research advances on infectious clones of hepatitis A,C and E viruses

我国是病毒性肝炎的高流行地区,各种病毒性肝炎均有较高的发病率,严重危害着我国人民的生命健康。因此,对肝炎病毒的相关研究尤为重要。病毒的感染性克隆是指能够产生具有感染性活病毒的遗传物质,是病毒研究领域的重要工具,可以弥补肝炎病毒研究领域缺乏细胞和动物模型的不足,用于揭示病毒基因结构及生物学功能,在病毒的分子生物学特征、致病机制、药物筛选等研究领域得到了广泛应用。本文将综述以RNA为遗传物质的肝炎病毒感染性克隆的建立、研究及应用进展,为甲型、丙型及戊型肝炎病毒的深入研究提供参考。

China is a highly endemic area of viral hepatitis,and the high prevalence rates of all types of viral hepatitis seriously endanger the health of Chinese people.Therefore,research on hepatitis viruses is particularly important.The infectious clone of viruses refers to the genetic material with the ability to generate infectious live viruses.It is an important tool in the field of virus research bypassing cell and animal models of hepatitis viruses to reveal the structure and biological function of virus genome and facilitate in-depth virus research.It has been widely used in the research of molecular biological characteristics,pathogenic mechanism and drug screening of multiple viruses.This review will focus on the establishment,research and application progress of the infectious clones of hepatitis viruses using RNA as genetic material,and provide references for the research of hepatitis A,C and E viruses.