青中年抑郁症患者认知功能与事件相关电位P300的相关性研究

Study on the correlation between cognitive function and event-related potential P300 in young and middle-aged patients with depression

目的探讨青中年抑郁症患者认知功能与事件相关电位P300的相关性。方法回顾性分析60例青中年抑郁症患者临床资料,均使用汉密尔顿抑郁量表(HAMD)评估其抑郁程度,根据其HAMD评分结果分为A组(>35分,重度抑郁症, 20例)、B组(20~35分,轻中度抑郁症, 40例)。两组均使用蒙特利尔认知评估量表(MoCA)评估认知功能状况,使用肌电/诱发电位仪进行事件相关电位P300检测,分析患者认知功能与事件相关电位P300的相关性。结果 A组MoCA评分为(20.90±2.15)分,低于B组的(23.97±2.04)分,差异有统计学意义(t=5.398, P=0.000<0.05)。A组潜伏期长于B组,波幅低于B组,差异有统计学意义(P<0.05)。经Pearson分析, P300潜伏期和MoCA评分呈负相关(r=-0.286,P<0.05);P300波幅和MoCA评分呈正相关(r=0.656, P<0.05)。结论青中年抑郁症患者认知功能与事件相关电位P300存在一定的相关性,可从神经电生理方面明确抑郁症患者存在认知功能损伤。

Objective To discuss the correlation between cognitive function and event-related potential P300 in young and middle-aged patients with depression. Methods A total of 60 young and middle-aged patients with depression were evaluated by the Hamilton depression scale(HAMD). According to their HAMD score, they were divided into group A(>35 points, severe depression, 20 cases) and group B(20-35 points, mild to moderate depression, 40 cases). Montreal cognitive assessment scale(MoCA) was used to assess cognitive function status, and myoelectric/evoked potential meter to detect event-related potential P300, and the correlation between patient’s cognitive function and event-related potential P300 was analyzed. Results MoCA score of group A was(20.90±2.15) points, which was lower than(23.97±2.04) points of group B, and the difference was statistically significant(t=5.398, P=0.000<0.05). The latency of group A was longer than that of group B, and the amplitude was lower than that of group B, and the difference was statistically significant(P<0.05). Pearson analysis showed that P300 latency was negatively correlated with MOCA score(r=-0.286, P<0.05);P300 amplitude was positively correlated with MOCA score(r= 0.656, P<0.05). Conclusion There is a certain correlation between cognitive function and event-related potential P300 in young and middle-aged patients with depression, which can be confirmed from the neurophysiological aspect that there is cognitive impairment in patients with depression.