探究老年食管鳞癌患者应用替吉奥同步放化疗的临床疗效

Clinical efficacy of concurrent radiotherapy and chemotherapy with tegafur in elderly patients with esophageal squamous cell carcinoma

目的探究替吉奥同步放化疗治疗老年食管鳞癌的临床效果。方法40例老年食管鳞癌患者,随机分为对照组和实验组,各20例。对照组患者单纯应用放疗治疗,实验组患者采用替吉奥同步放化疗治疗。对比两组患者的治疗效果及毒副反应发生情况。结果实验组患者的总有效率(RR)为85.00%,高于对照组的55.00%,差异有统计学意义(χ^2=4.286,P<0.05)。两组患者放射性肺炎、放射性食管炎、骨髓抑制及胃肠道反应发生率对比,差异无统计学意义(P>0.05)。结论针对老年食管鳞癌患者采用替吉奥同步放化疗治疗,能够在不增加毒副反应的同时提高临床效果,具有较高的可行性。

Objective To investigate the clinical effect of concurrent radiotherapy and chemotherapy with tegafur in elderly patients with esophageal squamous cell carcinoma.Methods A total of 40 elderly patients with esophageal squamous cell carcinoma were randomly divided into control group and experimental group,with 20 cases in each group.The control group was treated with chemotherapy alone,and the experimental group was treated with concurrent radiotherapy and chemotherapy with tegafur.The therapeutic effect and occurrence of toxic side effects were compared between the two groups.Results The response rate(RR)of the experimental group was 85.00%,which was higher than 55.00%of the control group,and the difference was statistically significant(χ^2=4.286,P<O.05).There was no statistically significant difference in incidence of radiation pneumonitis,radiation esophagitis,myelosuppression and gastrointestinal reactions between the two groups(P>0.05).Conclusion For elderly patients with esophageal squamous cell carcinoma,concurrent radiotherapy and chemotherapy with tegafur can improve the clinical effect without increasing toxic side effects,and has high feasibility.