南充市某三甲医院就诊女性人乳头瘤病毒阳性者多重型别感染情况分析

Multiple Infections of Female Patients With Positive Human Papillomavirus in a Third Grade Class-A Hospital in Nanchong City

目的了解南充市某三甲医院女性人乳头瘤病毒(HPV)阳性者多重型别感染情况现状,并探讨HPV多重型别感染的危险因素。方法将2018-06/2019-05在南充市某三甲医院妇科门诊就诊接受HPV检测的患者为研究对象,采用调查问卷的方式进行相关资料的收集,并采用非条件Logistic回归分析HPV阳性者多重型别感染的影响因素。结果 2 189例接受HPV检测的人员进行了调查,共检出HPV感染患者612例,HPV感染率为27.96%,单一感染375例(17.13%),多重感染237例(10.83%);多重型别感染患者以HPV16、HPV52、HPV58和HPV18为主。经非条件Logistic回归分析显示,性伴侣数量≥2个(OR=1.52,95%CI:1.06~2.18)、性生活前后无清洗习惯(OR=1.53,95%CI:1.03~2.26)、不使用避孕套(OR=1.59,95%CI:1.00~2.52)以及收入水平<4 000元/月(OR=1.53,95%CI:1.00~2.34)是女性HPV阳性者多重型别感染的危险因素。结论南充市某三甲医院女性HPV阳性者多重型别感染率略高于其他地区,且随着年龄增长,感染率有上升趋势,影响本地区HPV阳性患者多重型别感染的因素主要是性伴侣数量以及卫生不良习惯。

Objective To understand the status of multiple infections in female with human papillomavirus(HPV) and its risk factors in a third grade class-A hospital in Nanchong city. Methods From June2018 to May 2019,patients who received HPV test in the outpatient department of gynecology of a third grade class-A hospital in Nanchong were selected. Relevant information was collected by questionnaires. Unconditional logistic regression was used to analyze the influencing factors of multiple infections. Results A total of 2 189 female with HPV testing were investigated. A total of612 HPV-infected patients were detected, with a positive rate of 27.96%. Further, 375 cases(17.13%) were single infection, and 237 cases(10.83%) were multiple infections. Patients with multiple infections were mainly infected with HPV16, HPV52, HPV58 and HPV18. Unconditional logistic regression analysis showed that the risk factors of multiple infections in female HPV-positive patients were ≥2 sexual partners(OR=1.52, 95% CI: 1.06~2.18), no cleaning habits before and after sex(OR=1.53, 95% CI: 1.03~2.26), no condoms(OR=1.59, 95% CI: 1.00~2.52) and income level <4 000 yuan/month(OR=1.53, 95% CI: 1.00~2.34). Conclusion The rate of HPV infection in this hospital is slightly higher than that in other areas. The infection rate shows an upward trend with the increase of age. Main influencing factors of multiple infections in HPVpositive patients are the number of sexual partners and poor health habits in this hospital.