表皮生长因子受体酪氨酸激酶抑制剂导致皮肤不良反应7例临床分析

Clinical Analysis of Seven Cases of Cutaneous Adverse Reactions Due to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor

目的探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKIs)导致的皮肤不良反应。方法对7例因口服表皮生长因子受体酪氨酸激酶抑制剂导致皮肤不良反应患者进行临床、皮肤镜或病理检查,观察其结果并结合既往文献分析。结果表皮生长因子受体酪氨酸激酶抑制剂导致皮肤不良反应主要有:痤疮样疹、甲沟炎、皮肤干燥,相对少的是色素沉着、睫毛增粗和毛细血管扩张等。结论各类表皮生长因子受体酪氨酸激酶抑制剂导致类似皮肤不良反应,皮疹可能是靶向药物疗效观察的指标,皮肤科医生应及时报告并对症治疗。

Objective To discuss the cutaneous adverse reactions of epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs).Methods The cutaneous adverse reactions of seven patients caused by oral EGFR-TKIs were studied.The clinical characteristics,dermoscopic features and pathological examination were invesgated,and the relevant literature was reviewed.Results The common adverse reactions caused by EGFR-TKIs included acniform rash,paronychia,and exrosis,and less common cutaneous adverse reactions were hyperpigmentatio,trichomegaly and telangiectasias.Conclusion All kinds of EGFR-TKIs lead to similar cutaneous adverse reactions.Some eruptions maybe indicators of the efficacy of targeted drugs.Therefore,dermatologists should timely report and treat the symptoms.