宫颈低级别鳞状上皮内病变进展的预测因素

Predictors of Progression of Low-grade Squamous Intraepithelial Lesions

宫颈低级别鳞状上皮内病变(LSIL)是与宫颈癌及其癌前病变密切相关的一组宫颈病变。LSIL通常无须特殊处理,但部分患者存在进展为高级别病变甚至浸润癌的可能,从而需要采取手术治疗或其他干预措施。LSIL的发生发展是病毒因素、宿主免疫因素及不同细胞活动相互作用的一系列复杂过程。高危型人乳头瘤病毒的持续感染与LSIL的进展密切相关。随着分子生物学的发展及基因测序技术的不断成熟,许多新兴检测手段的出现(如DNA甲基化检测、p16/Ki-67双染检查)为预测LSIL进展提供了新思路。

Low-grade squamous intraepithelial lesion(LSIL)is a group of cervical lesions closely related to cervical cancer and precancerous lesions.The patients who are diagnosed LSIL by biopsy usually don′t need special treatments,but some patients may progress into high-grade squamous intraepithelial lesions or even invasive cancer,requiring surgical treatments or other interventions.The occurrence and development of LSIL are a series of complex processes involving viral factors,host immune factors,and the interactions of different cellular activities.A large number of existing studies have shown that the persistent infection of high-risk human papillomavirus is closely related to the progress of LSIL.In recent years,with the development of molecular biology and gene sequencing technology,many new detection methods have emerged,such as DNA methylation detection and p16/Ki-67 double staining,which have provided new ways to predict the progress of LSIL.