主观认知下降临床特点及影像研究进展

The research progress in clinical characteristics and imaging of subjective cognitive decline

主观认知下降(SCD)是一种个体自我感受认知功能较先前下降,但无客观神经心理异常证据的状态。众多证据表明,SCD可能是阿尔茨海默病(AD)疾病谱中最早的症状。同时,SCD具有很强的异质性,如何识别AD进展型的SCD患者以便实现AD超早期的预防和干预是当前研究的重点和难点。本综述从定义标准、认知进展因素、标志物研究现状、当前研究局限性及未来研究方向多方面陈述SCD相关内容。

Subjective cognitive decline(SCD)is a state in which an individual complains of a decline in cognitive function compared with the previous,while there is no objective evidence of neuropsychological abnormalities.Numerous evidences indicate that SCD may be the earliest symptom in Alzheimer's disease(AD)spectrum.At the same time,SCD presents a strong heterogeneity.How to identify progressive SCD patients in order to achieve ultra-early prevention and intervention of AD is of difficulty in the current research.This review presents SCD-related information in terms of research criteria,cognitive progress factors,marker research status,current research limitations,and future research directions.