白及多糖乳膏联合红花逍遥片治疗黄褐斑的疗效观察

Therapeutic effect of Bletilla Striata polysaccharide cream combined with Honghua Xiaoyao tablet on chloasma

目的:观察白及多糖乳膏联合红花逍遥片治疗黄褐斑的临床疗效。方法:选取十堰市太和医院(湖北医药学院附属医院)皮肤科2018年1-10月治疗的女性黄褐斑患者220例为研究对象,采用随机数字表法分为治疗组、对照组各110例,治疗组外用白及多糖乳膏治疗,早晚各1次,对照组外用千白乳膏治疗,早晚各1次,两组均口服红花逍遥片,每次1.17 g,每天3次,1个月为1个疗程,共治疗3个疗程。观察两组皮损评分、有效率、不良反应。结果:治疗3个疗程后,治疗组黄褐斑皮损评分为(0.93±0.31)分,有效率为84.55%(93/110),对照组皮损评分为(1.39±0.44)分,有效率为65.45%(71/110),两组差异均有统计学意义(t=9.901,χ2=11.594,均P<0.05);治疗组不良反应发生率显著低于对照组(χ2=4.053,P<0.05)。结论:白及多糖乳膏联合红花逍遥片治疗黄褐斑的疗效优于千白乳膏,不良反应发生率低。

Objective To observe the clinical efficacy of oral administration of Bletilla Striata polysaccharide cream combined with Honghua Xiaoyao tablet in the treatment of chloasma.Methods A total of 220 female patients with chloasma treated in the dermatology department of Taihe Hospital of Shiyan(Affiliated Hospital of Hubei Medical College)from January 2018 to October 2018 were enrolled.The patients were divided into treatment group and control group by random number table method,with 110 cases in each group.The treatment group was treated with Bletilla Striata polysaccharide cream,1 time in the morning and evening.The control group was treated with Qianbai cream,1 time in the morning and evening,and the two groups were treated with Honghua Xiaoyao tablets,each time 1.17g,3 times a day.One month was a course of treatment,a total of 3 courses of treatment.The effect was observed by skin lesion score,effective rate and adverse reaction.Results After 3 courses of treatment,the skin lesion score and effective rate in the treatment group were(0.93±0.31)points,84.55%(93/110),respectively,which in the control group were(1.39±0.44)points,65.45%(71/110),respectively,the difference between the two groups was statistically significant(t=9.901,χ2=11.594,all P<0.05).The incidence of adverse reactions in the treatment group was significantly lower than that in the control group(χ2=4.053,P<0.05).Conclusion The efficacy of Bletilla Striata polysaccharide cream combined with Honghua Xiaoyao tablet in the treatment of chloasma is better than Qianbai cream,and the incidence of adverse reaction is low.