扁桃体切除术后SAPHO患者骨痛、皮疹症状改善

Alleviation of skin lesions and bone pain in patients with SAPHO after tonsillectomy

目的观察难治性滑膜炎痤疮脓疱病骨肥厚骨髓炎(SAPHO)患者扁桃体切除术后皮疹、骨痛变化。方法记录术前、术后1、3、6、9、12个月、>12个月、>24个月、>48个月皮疹、骨痛情况。结果44例患者术后皮疹和骨痛显著改善。术后1个月皮疹、骨痛消失率分别为10%和28%,术后12个月分别为62%和77%。结论扁桃体切除术明显改善SAPHO患者的骨痛和皮损,扁桃体切除术可作为SAPHO、特别是难治性SAPHO患者的治疗方法之一。扁桃体炎可能与SAPHO发病相关。

Objective To evaluate the clinical efficacy of tonsillectomy on skin lesions and bone pain in patients with synovitis-acne-pustulosis-hyperostosis-osteitis(SAPHO).Methods Patients with SAPHO who were refractory to conservative treatment and then received tonsillectomy were recruited.The skin lesions were evaluated using palmoplantar pustulosis area and severity index(PPPASI)scoring.The pain was evaluated by the visual analog score(VAS).The scores of PPPASI and VAS at various follow-ups were recorded.ResultsForty-four patients(36 women and 8 men)with a median age of 37.3 years were enrolled.One month after tonsillectomy,skin lesions and bone pain disappeared in 10%and 28%respectively.The disappearance rates 12-month post-op,were 62%and 77%respectively.Conclusions Tonsillectomy exhibits inhibition to skin lesions and bone pain in the patients with SAPHO.Tonsillectomy is a potential alternative treatment for the refractory cases.