细胞焦亡与心血管疾病研究进展

Progress in research on pyroptosis and cardiovascular diseases

细胞焦亡是由gasdermin蛋白介导的程序性细胞死亡,包括依赖caspase-1的经典途径和依赖caspase-4、-5、-11的非经典途径,伴随着大量炎性因子的释放。动脉粥样硬化、心肌缺血以及心力衰竭等多种心血管疾病均与炎性反应密切相关。而细胞焦亡作为一种高度促炎性的细胞死亡也广泛参与了以上疾病的发生发展,在心血管相关疾病中发挥重要作用。

Pyroptosis is a kind of programmed cell death mediated by the gasdermin protein,including the classical pathway that depends on caspase-1 and the non-classical pathway that depends on caspase-4,-5,and 11,accompanied by the release of a large number of inflammatory factors.Atherosclerosis,myocardial ischemia,heart failure and other cardiovascular diseases are closely related to inflammatory response.Pyroptosis,as a highly pro-inflammatory cell death,is also widely involved in the occurrence and development of the cardiovascular diseases,and plays an important role in these diseases.