他克莫司与五味子及其制剂相互作用的系统评价

Systematic review on the interaction between tacrolimus and schisandra sphenanthera or its formulation

目的分析他克莫司与五味子及其制剂相互作用的研究进展,为临床合理用药提供借鉴。方法检索PubMed、Corchrane Library、Embase、中国知网、万方数据库,搜集他克莫司与五味子及其制剂五酯胶囊(片)相互作用的文献。检索时间为各数据库建库至2019年1月30日。结果共纳入65篇文献,其中论著56篇、案例报道7篇、综述2篇。研究结果显示联合使用五酯胶囊(片)的患者他克莫司的血药浓度高于单药组;五酯胶囊(片)可降低患者他克莫司的服药剂量,从而减少治疗费用;联合使用他克莫司和五酯胶囊(片)的有效性不低于单药组,且与单药组相比,不良事件发生率差异无统计学意义(P>0.05)。结论五味子及其制剂五酯胶囊(片)可对他克莫司产生增效作用,且安全有效,具有药物经济学优势。

Objective This study was designed to analyze the interaction between tacrolimus and schisandra sphenanthera or its formulation in order to provide support for rational drug use in clinical treatment.Methods PubMed,Corchrane Library,Embase,CNKI and Wanfang databases were searched,and the retrieval time was up to January 30,2019.Results A total of 65 literatures were identified,including 56 articles,7 case reports and 2 reviews.It was showed that the blood concentrations of tacrolimus in patients with combined use of Wuzhi capsules(tablets)was higher than those of single drug group;Wuzhi capsules(tablets)could reduce the dosage of tacrolimus and the treatment cost;the effectiveness of combined tacrolimus and Wuzhi capsules(tablets)was not lower than that of single drug group,There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion Schisandra sphenanthera or its formulation can safely and effectively enhance the treatment effect of tacrolimus,and has the advantages in pharmacoeconomics.