除草剂呋草酮的合成

Synthesis of Herbicide Flurtamone

[目的]研究除草剂呋草酮的合成方法。[方法]以间三氟甲基苯乙腈、苯乙酰氯为起始原料,经取代、环化、甲基化反应,处理后即得目标产物呋草酮。[结果]在优化反应条件下,反应总收率为80.4%(以间三氟甲基苯乙腈计),含量96%;产物结构经HPLC-MS、1H NMR确证。[结论]该反应原料易得,条件温和,操作简便,适合在工业上推广应用。

[Aims]This paper aims to study the synthetic method of flurtamone.[Methods]Flurtamone can be obtained through reactions of substitution,cyclization,methylation by using 3-trifluoromethylbenzylcyanide and phenylacetyl chloride as the starting materials.[Results]The total yield was 80.4%based on 3-trifluoromethylbenzylcyanide under the optimized reaction conditions and the purity was as high as 96%.The structure of the final product was confirmed by HPLC-MS and 1H NMR.[Conclusions]The method has advantages of commercially available raw materials,mild reaction condition,simple procedure,which is suitable for popularization and application in industry.