基于哈德曼编码的新型高分辨定域谱

High-Resolution Localized NMR Spectroscopy Based on Hadamard-Encoding

核磁共振(NMR)技术作为一种非植入无损伤的检测技术,已经广泛应用于化学、生物和医学等领域.本文基于哈德曼(Hadamard)编码的分子间单量子相干(iSQC)技术提出了一种新的序列,首先从理论上对该序列进行了简要的分析并阐明其原理,然后用套管模型实验和脑模型实验验证该序列在不均匀磁场下准确定域和快速获取高分辨谱的能力.实验表明,该序列在不均匀磁场下可以快速获取高分辨定域谱,同时抑制溶剂峰信号,具备一定的应用价值.

Nuclear magnetic resonance(NMR)is a non-invasive technology which has been widely used in chemical,biological and medical researches.This paper presents a new NMR pulse sequence based on Hadamard spatial encoding and intermolecular single-quantum coherence(iSQC)transfer.The principle of the sequence was analyzed and the theoretical considerations were presented.The performance of the sequence in accurate spatial localization and fast acquisition under inhomogeneous magnetic field were verified with phantom experiments and the brain metabolites experiments.The results demonstrated that the sequence can quickly obtain high-resolution localized spectra under inhomogeneous magnetic fields,while suppressing the solvent peaks efficiently.