核苷(酸)类似物在慢性乙型肝炎患者中的应用

Application of Nucleoside(Acid)Analogues in Patients with Chronic Hepatitis B

慢性乙型肝炎是我国常见的慢性传染病之一,多数患者病情呈慢性进行性发展。随着病情的进展,其可能发展为肝硬化或肝功能衰竭,严重威胁患者生命健康,是一个全球性的公共卫生问题。核苷(酸)类似物是治疗慢性乙型肝炎的有效药物,是以核苷(酸)为基础,进行各种化学基团修饰或取代而形成的核苷(酸)衍生物。本文就抗乙型肝炎病毒核苷(酸)类似物及不同患者核苷(酸)类似物选择作一综述,以期为临床合理应用核苷(酸)类似物提供参考。

Chronic Hepatitis B is one of the most serious clinical diseases,most patients with chronic progressive development of the disease.As the disease progresses,it can develop into cirrhosis of the liver or liver failure,a serious threat to the patient's life and health,and is a global public health problem.Nucleoside(acid)analogs are effective drugs for the treatment of chronic hepatitis B.Nucleoside(acid)derivatives are based on nucleoside(acid)and modified or substituted with various chemical groups.This article reviews the selection of anti-hepatitis B virus nucleoside(acid)analogues and nucleoside(acid)analogues in different patients,in order to provide references for the reasonable clinical application of nucleoside(acid)analogues.